NeoStrata Skin Care Products

NeoStrata brand professional skin care products are recommended by Dermatologists and Plastic Surgeons in over 42 countries and are the #1 recommended professional AHA skin care brand by physicians worldwide.

NeoStrata Professional products are uniquely formulated with Alpha hydroxyacids (AHA) and Polyhydroxy acids (PHA) to enhance the therapeutic treatments and skin care recommended by your physician. These patented alpha and polyhydroxy acids are beneficial in improving the visible signs of aging or sun damaged skin and for the treatment of various dermatological conditions including acne, dry skin, hyperkeratoses and hyperpigmentation. NeoStrata offers a range of products for the face and body with various concentrations of AHA and PHA ingredients as well as combinations with sunscreens (SPF), lightening, or anti-acne agents so that the appropriate therapy can be matched to any skin type or condition.

NeoStrata products are dermatologist and allergy tested, fragrance free, dye free, packaged in recyclable containers and are not tested on animals. Most NeoStrata products are proven to be non-comedogenic and non-acnegenic, and the NeoStrata PHA (polyhydroxy acid) formulations are hypoallergenic. The containers are sealed with tamper resistant safety seals to protect the product integrity until opened.

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Gluconolactone Products

NeoStrata's researchers have discovered an exciting new technology utilizing gluconolactone, which is exclusively available only through NeoStrata. Gluconolactone, the next generation of AHAs, is an antioxidant polyhydroxy acid (PHA) that is suitable for all skin types, even sensitive skin. This PHA is composed of multiple water-attracting hydroxyl groups, which hydrate the skin, resulting in enhanced degrees of moisturization.

Gluconolactone Improves Signs of Photoaging Among Women With Sensitive Skin

A gluconolactone regimen of cleanser, toner and topical moisturizer was assessed on 25 women with sensitive skin and moderate to advanced photoaging. All parameters of photoaging were significantly (p<0.05) reduced after six and twelve weeks of twice daily use, including firmness, sallowness, fine lines, wrinkles, roughness, hyperpigmentation and pore size. Mean relative percent improvements in clinical assessments ranged from 15% for hyperpigmentation to 33% for roughness. Silicone replica analysis revealed a reduction in the appearance of fine lines and wrinkles by over 30% in twelve weeks. Significant improvements were also observed in scaling of the skin (p<0.05). The products were well tolerated by the sensitive skin panelists and any preexisting irritation was improved (p<0.05) during treatment, including erythema, tightness and tingling.

Gluconolactone Regimen Compatible with Clinically Sensitive Skin

An open-label evaluation of the Exuviance Sensitive Skin System (cleanser, toner, moisturizers) was conducted on 30 females with acne rosacea (n=15) and atopic dermatitis (n=15). Compatibility of the test materials was determined by clinical assessments including physician global assessment and patient assessment. Following 12 weeks of twice daily use, results demonstrated compatibility with acne rosacea and atopic skin, with significant improvements (p<0.05) in skin texture, dryness, erythema and overall irritation in acne rosacea patients. Products were well tolerated on clinically sensitive skin.*

Gluconolactone Strengthens Skin Barrier Function

Following twice daily applications for four weeks of an AHA formulation (Glycolic Acid, 8% cream, pH 4.4) and PHA (Gluconolactone, 8% cream, pH 4.3) on volar forearms, treatment sites were patch-challenged with a common skin irritant Sodium Lauryl Sulfate (5%, aqueous) under occlusion for 6 hours. Barrier function of the skin was assessed during the 4 weeks of product usage and following SLS challenge (immediately, after 24 hours and after 48 hours) using Trans-Epidermal Water Loss (TEWL). Test product comparisons were made against a Vehicle (VEH) and Untreated (UNT) control.

Results indicate that skin sites treated with Gluconolactone exhibited statistically lower degrees of barrier dysfunction following SLS challenge in comparison to Glycolic Acid, vehicle and untreated sites, p<0.05. Glycolic Acid was not different from Untreated (p<0.05). British Journal of Dermatology 1997; 137: 934-938.

Lactobionic Acid Products

The latest skincare technology to emerge from NeoStrata utilizes Lactobionic Acid, a new polyhydroxy 'bionic' acid. Lactobionic acid is derived from naturally occurring lactose (milk sugar), and can be classified as a complex PHA (polyhydroxy AHA). It is an exciting new ingredient in skin care featuring potent antioxidant and humectant properties. This compound strongly attracts and binds water producing a natural gel matrix. Its unique film forming property provides desirable softness and a velvety smoothness to skin. Lactobionic acid is safe and non-irritating, and provides AHA anti-aging and cell turnover benefits to skin. Its primary use to date has been in medical applications including as an ingredient in preservation solutions for human organs for transplantation.

Glycolic Acid Products

NeoStrata utilizes Glycolic Acid, which is a natural constituent of sugar cane. It is the smallest molecule of the AHA family, and therefore is optimally absorbed into the skin. Clinical studies have shown that NeoStrata Glycolic Acid products used in a daily regimen reduces the appearance of fine lines and wrinkles and makes skin look younger.


Glucoheptonolactone is a naturally occurring ingredient that is an antioxidant PHA (polyhydroxy acid) and is a slightly larger molecule than gluconolactone with additional water-attracting hydroxyl groups. Due to its PHA structure, glucoheptonolactone is used to provide moisturization, skin conditioning, anti-aging and anti-oxidant benefits.

Mandelic Acid Products

A highly lipophilic AHA that is ideal for oily and acne prone skin.

NeoHydroxy Complex

A unique combination of AHAs and PHAs (polyhydroxy acids).

 Frequently asked questions about Neostrata:

What is the difference between Bio-Hydrating Cream and Bionic Face Cream?


 The Bio-Hydrating Cream contains 15% gluconolactone and is promoted for use with adult acne and as the "NeoStrata-15" PHA product. The Bionic Face Cream contains 8% gluconolactone with 4% lactobionic acid and is intended for intense moisturization of dry, photoaged skin, or for use following non-ablative laser, microdermabrasion and peels.

How does Lactobionic Acid affect pore size, and improve uneven pigmentation? 

It is believed that the AHAs / PHAs affect pore size by helping to cleanse out cellular debris and also enhance skin elasticity. The epidermal cell turnover effects and normalization process help to correct hyperpigmentation and promote a more even appearance.

Does NeoStrata Company use Animal Derived Ingredients? 

NeoStrata Company endeavors to use non-animal derived ingredients whenever possible, by substituting plant-derived and synthetic materials in their place.


Please visit us at, call us at 847.696.9900 or email us at for a skin consultation and/or NeoStrata Product recommendations.


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