Patient Portal

12 Hallmarks of Aging

  • Genomic Instability: Environmental and cellular processes damage your genes over time, accelerating your aging through free radicals
  • Telomere Attrition: Your chromosomal end-caps or telomeres shorten during DNA replication, leading to cell division cessation and disease
  • Epigenetic Alterations: Environmental factors alter your gene expression over time, affecting how DNA sequences are read and utilized
  • Loss of Proteostasis: Your proteins misfold and malfunction over time, causing certain neurological diseases and cancer
  • Deregulated Nutrient-Sensing: Changes in your body nutrients affect metabolic pathways, impacting longevity-related proteins like IGF-1 and mTOR
  • Mitochondrial Dysfunction: Your mitochondrial performance declines with age, causing fatigue and chronic illness symptoms
  • Cellular Senescence: As you age, cells stop dividing and accumulate, causing increased inflammation and tissue dysfunction
  • Stem Cell Exhaustion: Aging significantly reduces the volume and quality of stem cells, impairing body repair and renovation
  • Altered Intercellular Communication: Your aging disrupts cellular communication, decreasing information transmission between cells
  • Disabled Macroautophagy: Impaired autophagy prevents your normal cell cleaning processes, leading to buildup of toxins and cellular dysfunction
  • Chronic Inflammation: Persistent inflammation with aging contributes to various age-related diseases by continuously damaging tissues
  • Dysbiosis: Imbalances in your microbial communities, particularly in the gut, affect metabolic and immune functions, impacting health
Plastic Surgery Safety
Critical-Questions

By Dr. SAM SPERON

When I first published The 7 Critical Questions to Ask Before Letting Any Surgeon Touch You, I had no idea that it would be so popularly received. Since its publication, this brief guide has helped thousands like you to more safely navigate the world of cosmetic surgery. The 7 Questions have been updated and a bonus section, Applying the 7 Questions, has just been added. Be my guest to read, learn and share.